母体吸烟与基因对子代出生体重的交互影响
The Interplay between Maternal Smoking and Genes in Offspring Birth Weight
Journal of Human Resources · 2022 · [{"name": "Rita Dias Pereira", "affiliation": ["Tinbergen Institute", "Erasmus University Rotterdam"]}, {"name": "Cornelius A. Rietveld", "affiliation": ["Erasmus University Rotterdam"]}, {"name": "Hans van Kippersluis", "affiliation": ["Tinbergen Institute"]}]
中文摘要
已有充分证据表明，出生体重受到儿童遗传禀赋与母体孕期吸烟的共同影响。本文考察遗传禀赋与母体吸烟对出生体重是否存在交互作用。我们使用位于烟碱受体基因CHRNA3上的遗传变异（rs1051730）作为母体吸烟决策的工具变量，并利用孕期采集的烟碱生物标志物来处理母体吸烟低报问题。我们确认，遗传禀赋与母体吸烟均会对儿童出生体重产生负向影响。然而，我们没有发现遗传禀赋与母体吸烟之间存在具有实质意义交互作用的证据。
Abstract
It is well-established that birth weight is affected by the child's genetic endowments and maternal smoking during pregnancy. Here, we investigate whether an interaction between genetic endowments and maternal smoking on birth weight exists. We instrument the maternal smoking decision with a genetic variant (rs1051730) located in the nicotine receptor gene CHRNA3 and deal with the underreporting of maternal smoking by using a biomarker of nicotine collected during pregnancy. We confirm that genetic endowments and maternal smoking negatively affect the child's birth weight. However, we do not find evidence of meaningful interactions between genetic endowments and maternal smoking.