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形成阿片类药物依赖的路径:来自急诊科诊疗实践差异的证据

Pathways into Opioid Dependence: Evidence from Practice Variation in Emergency Departments
American Economic Journal: Applied Economics · 2022 · Sarah Eichmeyer、Jonathan Zhang

中文摘要

我们利用医生之间的诊疗实践差异,揭示医疗服务在导致阿片类药物依赖中的作用。利用200万名有急诊就诊经历的美国退伍军人的健康记录,我们发现,与被准随机分配给处方开具水平处于最低十分位组的医生相比,被准随机分配给最高十分位组的医生会使患者后续的阿片类药物使用率和误用率在统计上显著提高。工具变量结果表明,获得阿片类药物处方会使长期使用处方阿片类药物的概率相对增加20%,并大幅提高阿片类药物使用障碍的发生率和阿片类药物过量使用死亡率。我们还发现提示性证据,表明处方阿片类药物暴露会导致转向使用非法阿片类药物。

Abstract

We use practice variation across physicians to uncover the role of medical care in causing opioid dependence. Using health records of 2 million US veterans with emergency department visits, we find that quasi-random assignment to a top (versus bottom) decile prescribing provider significantly increases subsequent opioid use and misuse rates. Instrumental variable results show that opioid prescription receipt leads to a 20 percent increase in the probability of long-term prescription opioid use and sizable increases in the development of opioid use disorder and opioid overdose mortality. We find suggestive evidence of transition into illicit opioids due to prescription opioid exposure. (JEL I11, I12, I18)
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