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基因预测与逆向选择

Genetic Prediction and Adverse Selection
Econometrica · 2026 · Eduardo Azevedo、Jonathan Beauchamp、Richard Karlsson Linnér

中文摘要

近期的进展大幅提升了我们利用基因数据预测疾病风险的能力。对此,许多国家已禁止保险公司使用基因数据,尽管此举引发了对逆向选择的担忧。本文测度了一个市场中的逆向选择:保险公司只能依据非基因信息进行核保,而消费者还能够获取基因信息。为此,我们结合了数量遗传学方法、经济理论中的选择度量指标,以及英国生物样本库中近50万人的基因数据和电子健康记录数据。我们聚焦于重大疾病保险市场,考察消费者能够获取当前或预期未来的基因预测技术的情景。我们发现,使用当前预测技术时,逆向选择的程度已较为明显;而使用预期未来的技术时,逆向选择可能严重到使市场难以正常运作。

Abstract

Recent advances have substantially improved our ability to predict disease risk with genetic data. In response, many countries have banned insurers from using genetic data, despite concerns about adverse selection. This paper measures adverse selection in a market where insurers can underwrite only on nongenetic information while consumers also have access to genetic information. We do so by combining methods from quantitative genetics, selection measures from economic theory, and genetic and electronic health record data on nearly 500,000 individuals in the UK Biobank. We focus on the critical illness insurance market and consider scenarios in which consumers have access to current or expected future genetic prediction technology. We find noticeable levels of selection with current prediction technology, and potentially crippling selection with expected future technology.
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