社会经济健康差距的终生轨迹及其驱动因素

中文摘要

我们利用荷兰Lifelines队列研究与生物样本库的纵向生物标志物数据，考察社会经济健康差距的终生轨迹。通过使用12项生物标志物构建累积生理负荷指数，我们分析了健康的动态变化及其在生命周期中与社会经济地位（SES）的关联。研究发现，与较低SES相关的健康风险很早便已显现，并先于慢性疾病的发生。进一步分析考察了累积生理负荷的驱动因素，并强调了健康行为的作用。我们的研究凸显了针对SES相关健康差距进行早期干预的必要性，并为理解SES与长期健康结果之间的生理路径提供了新的见解。

Abstract

<h3>Abstract</h3> We investigate lifetime socioeconomic health disparities through longitudinal biomarkers from the Dutch Lifelines cohort study and biobank. By constructing an allostatic load index from 12 biomarkers, we analyze the dynamics of health and its association with socioeconomic status (SES) over the life cycle. Our findings reveal that health risks linked to lower SES emerge early and precede chronic disease onset. Further analyses investigate the drivers of allostatic load and emphasize health behaviors. Our research highlights the need for early interventions targeting SES-related health disparities and provides new insights into the physiological pathways linking SES to long-term health outcomes.