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竞争至关重要:药品的统一定价与基于适应症的定价

Competition matters: Uniform vs. indication-based pricing of pharmaceuticals
Journal of Health Economics · 2026 · Kurt Richard Brekke、Dag Morten Dalen、Odd Rune Straume

中文摘要

药品支出正在迅速上升,部分驱动因素是可治疗多种疾病的高效但极其昂贵的药物疗法的创新,这意味着支付方面临成本控制与新药可及性之间的关键权衡。一个关键的政策问题是,应将生产商限制为统一定价,还是允许其采用基于适应症的定价,即价格因患者群体而异。我们使用双市场模型分析这一选择如何影响药品生产商投资新适应症的激励、其定价策略以及由此给医保计划带来的剩余。在垄断情形下,基于适应症的定价带来更高利润,从而强化了投资新适应症的激励;而支付方则偏好统一定价,除非固定投资成本无法收回。然而,如果多适应症生产商在其中一个市场面临治疗性竞争,基于垄断情形得出的结论可能不再成立。具体而言,我们识别出一种竞争软化效应:统一定价限制可作为在竞争性市场中提高价格的可信承诺。在这种情况下,医保计划可能偏好基于适应症的定价以降低成本。总体而言,我们的发现表明,两种定价方案都不是普遍最优的,凸显了针对不同药品类别逐案评估的必要性。

Abstract

Pharmaceutical expenditures are rising rapidly, driven in part by the innovation of highly effective but very expensive drug therapies that treat multiple diseases, implying that payers face a critical trade-off between cost containment and access to new medicines. A key policy question is whether producers should be restricted to uniform pricing or allowed to use indication-based pricing, where prices vary across patient groups. We use a two-market model to analyse how this choice affects drug producers' incentives to invest in new indications, their pricing strategies, and the resulting surplus for health plans. In a monopoly setting, indication-based pricing yields higher profits and thus strengthens incentives to invest in new indications, while the payer prefers uniform pricing unless the fixed investment costs cannot be recouped. However, monopoly-based insights may not hold if the multi-indication producer faces therapeutic competition in one of the markets. Specifically, we identify a softening-of-competition effect, where a uniform pricing restriction serves as a credible commitment to raise prices in the competitive market. In this case, the health plan might favour indication-based pricing to reduce costs. Overall, our findings suggest that neither pricing scheme is universally optimal, underscoring the need for case-by-case assessments across drug classes.
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